The emerging infectious diseases and their number one causes pose a challenge to international stability worldwide. The epidemic of emerging and re-emerging diseases causes many problems for health systems, especially for the medical staff, which require global action in this regard. Emerging infectious diseases are a growing problem for the global community that accompanies the increasing danger of severe health, environmental, economic, and social impacts. An ideal emerging disease preparedness and response environment would strive for collaboration among all sectors impacted by the area unit as a business and social commitment to enhance the capacity of nations and communities to respond to threats as they arise. This article highlights the significant issues that should be considered in emerging and re‐emerging diseases, which could help the policymakers to set effective policies for dealing with the diseases and to evaluate the impact of previous health interventions better at the community level.